Research focus
About the research
How do the structures of large protein and protein–nucleic acid assemblies determine their regulation and function at molecular resolution?
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The Chang group focuses on cryo-electron microscopy and biochemical reconstitution to solve structures of large complexes. Researchers apply X-ray crystallography, NMR, electron tomography, and advanced spectroscopy alongside computational approaches to examine nucleic acid and protein structures. Current projects document CRISPR-Cas systems and cell-cycle regulatory assemblies using structural methods to reveal mechanisms of action.
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