Research focus
About the research
Can programmable DNA and RNA devices be built to sense metabolites and control cellular information flow with spatial precision?
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The You Research Group engineers genetically encoded fluorescent RNA sensors for cellular imaging of metabolites and small molecules. The group images force transduction at cell–cell junctions using single-molecule level approaches to study mechanotransduction. Researchers perform in vivo selection and high-throughput evolution of aptamers to discover functional nucleic acid binders inside living cells. The lab designs conditional self-assembly mechanisms for DNA/RNA nanostructures to enable programmable diagnostics and delivery platforms.
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