Research focus
About the research
How does the cell adhesion–cytoskeleton machinery coordinate tissue architecture during development and tumor formation?
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The lab uses Drosophila genetics and cultured human colon cells to dissect how APC regulates Wnt signaling and the cytoskeleton. Researchers combine confocal live-imaging and fluorescently-tagged proteins to visualize junction–cytoskeleton dynamics during morphogenetic events such as dorsal closure. The group interrogates destruction-complex assembly and APC’s catalytic cycle to explain regulated ß-catenin stability in Wnt signaling. They investigate centrosome functions, mitotic fidelity regulators, checkpoints and apoptosis to understand genome stability mechanisms in epithelial cells.
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