Research focus
About the research
Can novel synthetic and medicinal-chemistry methods yield small molecules that modulate challenging biological targets?
Read the full research overview
The Wipf Group pursues total synthesis, strain-release and heterocyclic chemistry to access diverse scaffolds for biological testing. Medicinal-chemistry and structure–activity studies optimize small molecules as inhibitors or modulators of protein targets, including p97/VCP and PTP4A3, with the goal of generating probes and therapeutic leads. Collaborative translational projects apply these compounds in cancer, neurodegeneration, and radiation-mitigation studies.
Selected publications
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