About the research
How does purinergic signaling regulate renal water and sodium handling and metabolic responses to diet?
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The Kishore Lab investigates purinergic signaling mediated by extracellular nucleotides and nucleosides in renal physiology and pathophysiology. Researchers study specific P2Y receptors (P2Y2 and P2Y12) as targets for treating water-balance disorders and diet-induced obesity and insulin resistance. The group examines CD39 (NTPDase1) roles in kidney regulation of water and sodium handling using collaborative experimental models. Projects include inducing proliferation of erythropoietin-producing kidney cells as a potential therapy for anemia of chronic kidney disease.
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