Sidi Chen Research Group

The Chen lab performs genome-scale in vivo CRISPR and CRISPRa screens in T cells and tumors to discover regulators of T cell infiltration, degranulation, and tumor immune evasion. The group develops AAV- and CRISPR-based engineering platforms (for example MAEGI and AAV-Cpf1 KIKO) to create and test immune-gene and CAR-T engineering strategies in mouse tumor models. Researchers combine high-throughput genetic screens with precision in vivo cancer models to map tumor-intrinsic suppressors and immune modulators. Technology development includes spatial and scalable perturbation methods to enable therapeutic target discovery.